Immunohistochemical Study of Mammary Gland Carcinoma
Objective: To study the association between different elements immunohistochemical morphologic aspects and their possible prognostic value.
Methods: A descriptive-retrospective of 651 years of breast cancer cases with immunohistochemical staining in the Vargas Hospital of Caracas from May 2001 to July 2004. We analyzed the morphological characteristics of different tumor types, using the classification of Scarff-Bloom-Richardson amended, relating to the expression of different immunohistochemical markers: estrogen receptors, progesterone receptors, c-erb B-2 and Ki-67, made by biotin-streptavidin technique.
Results: The mean age was 51.72 years. The most common tumor was infiltrating ductal carcinoma (88.7%), followed by invasive lobular carcinoma (4.6%). 5.5% of ductal carcinomas were well differentiated, moderately differentiated 42.3%, 52.2% were poorly differentiated, of these, 77% had estrogen receptor and progesterone <10%, the well-differentiated carcinomas showed variable positivity. Poorly differentiated tumors showed c-erb B-2 positive in 51.36%, well differentiated between the 81.84% were negative, the intraductal carcinoma was positive in 42.86%, usually associated with comedocarcinoma. The 94.37% of poorly differentiated tumors were Ki-67 positive.
Conclusions: infiltrating ductal carcinoma is the classic type most common malignant tumor of the mammary gland, with an average age of 51.55 years, is often differentiated, possibly involving tumors with aggressive biological behavior. This is evidenced by negativity for hormone receptors and increased expression of c-erb B-2 and Ki-67.